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SEC Form 4 research

Upstream Bio, Inc. insider transactions

Inspect Upstream Bio, Inc.'s public SEC insider acquisitions and sales, reporting owners and source receipts.

As of 2026-10-15T08:02:39.132Z

Issuer CIK
0002022626
Reporting owners
21
Officers and directors
8
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What is a Form 4?

Animation: what a Form 4 is, shown with one real example. Sonic Automotive (SAH) reporting owner Paul P. Rusnak bought 13,701 shares at $59.78 on Wednesday, October 7, 2026, transaction code P, an open-market purchase (S is a sale and A is an award from the company). A timeline marks the SEC's two-business-day filing deadline, which ends Friday, October 9. The SEC accepted the Form 4 at 4:33:21 PM ET on October 9, and NexusTrade treats it as public one minute later, at 4:34:21 PM ET. A lamp for NexusTrade's InsiderTrades indicator stays off from the trade date until that moment, then counts one purchase worth 13,701 × $59.78 = $819,045.78.
In this example the shares were bought on Oct 7, 2026, and NexusTrade's InsiderTrades indicator can count the purchase starting at 4:34:21 PM ET on Oct 9, one minute after the SEC accepted the Form 4.

A Form 4 is the SEC filing a company insider, such as an officer, director or 10% owner, uses to report a trade in the company's stock, generally within two business days. The animation follows one real filing as an example: Paul P. Rusnak's purchase of Sonic Automotive (SAH) shares on October 7, 2026.

The same reading applies to every row on this page. The trade date is when the shares changed hands. The available date is when NexusTrade treats the filing as public, and a NexusTrade InsiderTrades indicator counts a purchase (code P) or sale (code S) only from that moment. Code A awards are not counted as purchases.

Read one actual disclosure before using it

Show the table · 1 row, 7 columns

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2026-09-172026-09-16GRAY MICHAELS853$5.49Not reported

First displayed source row from Recent insider disclosures. The full bounded history and coverage notes remain below.

The displayed observation date is 2026-09-16 and its public availability date is 2026-09-17. Subtracting those calendar dates gives 1 day of disclosure lag. Historical public research can use the record from the availability date, rather than backdating knowledge to the observation date. The calendar-day difference does not assert an intraday publication time.

This row is code S: a sale. A purchase-following rule excludes this sale even if the reported dollar amount is large.

Open the linked original receipts to verify the row, then inspect a second record before drawing a pattern. This public filing observation supplies source evidence, not a completed copy-trading return.

Recent insider disclosures

This table includes purchases, sales and awards in the public filing record. Awards and open-market purchases are distinct transaction codes. For historical research, use the public availability date to determine when the transaction was knowable.

Read code P as a purchase, S as a sale and A as an award. An award is an acquisition, but it is not an open-market purchase. Open the filing receipt to check the transaction details.

Show the table · 5 rows, 7 columns

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2026-09-172026-09-16GRAY MICHAELS853$5.49Not reported
2026-09-172026-09-16Ambrose AllisonS485$5.49Not reported
2026-09-172026-09-16Deykin AaronS895$5.49Not reported
2026-09-172026-09-16Sutherland Everett RandS2,095$5.49Not reported
2026-09-172026-09-16Houghton AdamS700$5.49Not reported

Most recent 90-day source activity, up to 50 rows. No rows means no matching recent records, not no historical activity.

Officers and directors in the directory

Show the table · 10 rows, 3 columns

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OrbiMed Capital GP VIII LLC000184580495
Chimovits Erez000170639923
OrbiMed Israel GP II, L.P.000168209073
Ambrose Allison00020473813
Deykin Aaron00020316933
GRAY MICHAEL000127141110
Houghton Adam00020316913
OrbiMed Advisors Israel II Ltd000168209373
ORBIMED ADVISORS LLC00010559511,020
Sutherland Everett Rand00018528804

Which transactions qualify for the company tracker

The company strategy uses verified officers and directors with qualifying acquisitions at this issuer. Other reporting owners may appear in source records without becoming strategy signals.

Strategy eligibility is held while filing coverage is unresolved.

Historical follower simulations are separate from these source transactions. They do not establish live trading results.