Public ownership evidence

Upstream Bio, Inc. Common Stock (UPB) Ownership Disclosures

Read UPB insider transactions, institutional 13F filings and Congressional disclosures with report dates, public availability and original receipts.

As of 2026-10-10T12:08:28.848Z

Recent Form 4 activity

2026-09-172026-09-16GRAY MICHAELS853Not reported
2026-09-172026-09-16Ambrose AllisonS485Not reported
2026-09-172026-09-16Deykin AaronS895Not reported
2026-09-172026-09-16Sutherland Everett RandS2,095Not reported
2026-09-172026-09-16Houghton AdamS700Not reported

90-day public availability window, up to 50 records.

Recent institutional filing receipts

These are raw ticker-matched positions in recent 13F receipts, including amendments. They are not deduplicated current ownership totals. Open the manager profile to inspect its effective filing book.

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM2026-06-302026-08-2538,634$267,347None
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM2026-06-302026-08-25267,347$38,634,000None
MERCER GLOBAL ADVISORS INC /ADV2026-06-302026-08-2013,352$92,396None
Stonepine Capital Management, LLC2026-06-302026-08-1833,432$231,349None
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO2026-06-302026-08-184,700$32,524None
Wellington Grp LLC2026-06-302026-08-153,000$27,000None
Graham Capital Management, L.P.2026-06-302026-08-1522,508$155,755None
SEI INVESTMENTS CO2026-06-302026-08-1520,026$138,580None
JPL Wealth Management, LLC2026-06-302026-08-1514$97None
Quarry LP2026-06-302026-08-15893$6,180None
ENAVATE SCIENCES GP, LLC2026-06-302026-08-152,459,703$17,021,145None
DIADEMA PARTNERS LP2026-06-302026-08-1519,093$132,124None
XTX Topco Ltd2026-06-302026-08-15242,346$1,677,034None
CHARLES SCHWAB INVESTMENT MANAGEMENT INC2026-06-302026-08-15262,456$1,816,196None
Sixth Street Partners Management Company, L.P.2026-06-302026-08-15262,456$1,816,196None
SAMSARA BIOCAPITAL, LLC2026-06-302026-08-15353,717$2,447,722None
ExodusPoint Capital Management, LP2026-06-302026-08-1541,045$284,031None
Qube Research & Technologies Ltd2026-06-302026-08-15978,500$6,771,220None
Shay Capital LLC2026-06-302026-08-1518,000$124,560None
OSAIC HOLDINGS, INC.2026-06-302026-08-1519$131None
Schonfeld Strategic Advisors LLC2026-06-302026-08-15225,760$1,562,258None
Squarepoint Ops LLC2026-06-302026-08-15290,904$2,013,056None
Man Group plc2026-06-302026-08-1573,823$510,855None
Trexquant Investment LP2026-06-302026-08-15466,430$3,227,696None
MetLife Investment Management, LLC2026-06-302026-08-1520,852$144,296None
Engineers Gate Manager LP2026-06-302026-08-1512,491$86,438None
JANE STREET GROUP, LLC2026-06-302026-08-154,420$30,586None
JANE STREET GROUP, LLC2026-06-302026-08-1511,174$77,324None
JANE STREET GROUP, LLC2026-06-302026-08-1511,900$82,348Call
SPHERA FUNDS MANAGEMENT LTD.2026-06-302026-08-15219,700$1,520,324None
Legal & General Group Plc2026-06-302026-08-154,962$34,337None
Legal & General Group Plc2026-06-302026-08-153,889$26,912None
Legal & General Group Plc2026-06-302026-08-153,710$25,673None
HRT FINANCIAL LP2026-06-302026-08-15170,590$1,180,000None
SUSQUEHANNA INTERNATIONAL GROUP, LLP2026-06-302026-08-1510,100$69,892Call
Stonepine Capital Management, LLC2026-06-302026-08-1533,432$231,349None
Parkman Healthcare Partners LLC2026-06-302026-08-15935,247$6,471,909None
Verdad Advisers, LP2026-06-302026-08-1521,810$150,925None
MILLENNIUM MANAGEMENT LLC2026-06-302026-08-151,143,775$7,914,923None
Boxer Capital Management, LLC2026-06-302026-08-15150,000$1,038,000None
AMERIPRISE FINANCIAL INC2026-06-302026-08-1510,487$72,570None
Bain Capital Life Sciences Investors, LLC2026-06-302026-08-15600,949$4,158,567None
Freestone Grove Partners LP2026-06-302026-08-151$7None
ORBIMED ADVISORS LLC2026-06-302026-08-155,693,589$39,399,636None
Woodline Partners LP2026-06-302026-08-15831,481$5,753,849None
AQR CAPITAL MANAGEMENT LLC2026-06-302026-08-158$55None
AQR CAPITAL MANAGEMENT LLC2026-06-302026-08-15854$5,910None
AQR CAPITAL MANAGEMENT LLC2026-06-302026-08-15541,205$3,745,139None
AQR CAPITAL MANAGEMENT LLC2026-06-302026-08-1523$159None
AQR CAPITAL MANAGEMENT LLC2026-06-302026-08-151,709$11,826None

90-day public filing window, up to 50 source positions.

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM ↗CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM ↗MERCER GLOBAL ADVISORS INC /ADV ↗Stonepine Capital Management, LLC ↗PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO ↗Wellington Grp LLC ↗Graham Capital Management, L.P. ↗SEI INVESTMENTS CO ↗JPL Wealth Management, LLC ↗Quarry LP ↗

Recent Congressional disclosures

No matching Congressional transactions were returned in this source preview.

No records are available for this view.

Bounded public source preview, up to 25 disclosed events.

How to read the disclosure dates

The tables report different things: insider transactions, institutional positions and Congressional transaction ranges. Read each table with its source dates and units. They cannot be added into a combined ownership percentage.

  1. Company insiders

    SEC Form 4 purchases, sales and awards report transactions and their public filing availability.

  2. Institutional managers

    13F reports disclose delayed quarter-end positions. They are not a record of trades between quarters.

  3. Congressional filers

    Periodic transaction reports disclose transaction dates and amount brackets. Public filing dates determine what researchers could know.

Institutional source directory ↗Congressional source directory ↗

Read the transaction codes

Awards use transaction code A, purchases P and sales S. An acquisition from an award is not the same as an open-market purchase. Joint filers may share a transaction. Use original receipts and availability dates to interpret the events.