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SEC Form 13F

Opaleye Management Inc. 13F Holdings

Inspect Opaleye Management Inc.'s 2026-06-30 SEC 13F positions, public filing date, amendments and original receipt.

As of 2026-08-15T03:59:59.999Z

Report period
2026-06-30
Publicly available
2026-08-15
Reported value
$1,104,182,260
Positions
58
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Disclosed positions

Largest disclosed position values

Scale: 0 to 195,140,000 USD · zero baseline

Largest disclosed position values

  • LQDA · COM NEW+195,139,175 USD
  • ETON · COM+103,532,000 USD
  • HROW · COM+101,928,000 USD
  • IRON · COM+62,534,700 USD
  • URGN · COM+52,991,853 USD
  • APGE · COM+51,764,700 USD
  • MGTX · COM+47,960,500 USD
  • SOL-GEL TECHNOLOGIES LTD · SHS NEW+37,070,000 USD
  • RZLT · COM NEW+32,760,000 USD
  • TGTX · COM+29,392,900 USD

Reported underlying-position values for 2026-06-30, publicly available 2026-08-15. Put/call values are not option premiums; this subset is not a complete portfolio allocation. Exact issuer, class and unit remain in the table. Showing the first 10 of 50 recorded values; the complete table remains available below.

Inspect all 50 displayed rows: Disclosed positions

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LIQUIDIA CORPORATIONLQDACOM NEW$195,139,1752,447,500SHNone
ETON PHARMACEUTICALS INCETONCOM$103,532,0002,860,000SHNone
HARROW INCHROWCOM$101,928,0002,400,000SHNone
DISC MEDICINE INCIRONCOM$62,534,700855,000SHNone
UROGEN PHARMA LTDURGNCOM$52,991,8531,439,996SHNone
APOGEE THERAPEUTICS INCAPGECOM$51,764,700390,000SHNone
MEIRAGTX HLDGS PLCMGTXCOM$47,960,5003,550,000SHNone
SOL-GEL TECHNOLOGIES LTDUnresolvedSHS NEW$37,070,000500,000SHNone
REZOLUTE INCRZLTCOM NEW$32,760,0006,300,000SHNone
TG THERAPEUTICS INCTGTXCOM$29,392,900535,000SHNone
IMMIX BIOPHARMA INCIMMXCOM$24,176,9502,345,000SHNone
CRESCENT BIOPHARMA INC.CBIOCOM$23,748,3181,319,351SHNone
STOKE THERAPEUTICS INCSTOKCOM$22,904,000700,000SHNone
ALPHA COGNITION INCACOGCOM NEW$20,905,2722,895,467SHNone
EDGEWISE THERAPEUTICS INCEWTXCOM$20,315,000500,000SHNone
REVOLUTION MEDICINES INCRVMDCOM$18,728,000100,000SHNone
MONTE ROSA THERAPEUTICS INCGLUECOM$18,029,000745,000SHNone
ALUMIS INCALMSCOM$15,477,000550,000SHNone
CODEXIS INCCDXSCOM$15,334,1006,785,000SHNone
REPLIMUNE GROUP INCREPLCOM$15,331,8731,384,993SHNone
XOMA ROYALTY CORPORATIONXOMACOM NEW$14,380,895338,374SHNone
MBX BIOSCIENCES INCMBXCOM$14,352,000260,000SHNone
RHYTHM PHARMACEUTICALS INCRYTMCOM$13,601,175122,500SHNone
EDITAS MEDICINE INCEDITCOM$12,512,6533,861,930SHNone
PROTAGONIST THERAPEUTICS INCPTGXCOM$12,258,000100,000SHNone
CABALETTA BIO INCCABACOM$12,016,4183,863,800SHNone
Q32 BIO INCQTTBCOM$11,860,940931,000SHNone
ANNEXON INCANNXCOM$9,789,5151,714,451SHNone
VERASTEM INCVSTMCOM NEW$6,876,0001,800,000SHNone
ZENTALIS PHARMACEUTICALS INCZNTLCOM$6,851,3821,412,656SHNone
RELMADA THERAPEUTICS INCRLMDCOM$6,470,200935,000SHNone
OCULAR THERAPEUTIX INCOCULCOM$5,892,000600,000SHNone
TREVI THERAPEUTICS INCTRVICOM$5,781,500310,000SHNone
BRIDGEBIO ONCOLOGY THERAPEUTBBOTCOM NEW$5,334,000700,000SHNone
LYELL IMMUNOPHARMA INCLYELCOM NEW$4,833,551344,025SHNone
OPUS GENETICS INCIRDCOM$4,623,7501,125,000SHNone
4D MOLECULAR THERAPEUTICS INFDMTCOM$4,448,012334,437SHNone
INTELLIA THERAPEUTICS INCNTLACOM$4,230,000250,000SHNone
VOYAGER THERAPEUTICS INCVYGRCOM$4,147,5001,185,000SHNone
BIODESIX INCBDSXCOM$4,059,000180,000SHNone
ROCKET PHARMACEUTICALS INCRCKTCOM$3,420,0001,000,000SHNone
JADE BIOSCIENCES INCJBIOCOM NEW$3,221,900145,000SHNone
SANUWAVE HEALTH INCSNWVCOM$3,061,400306,140SHNone
FORTRESS BIOTECH INCFBIOCOM NEW$2,723,400890,000SHNone
JOURNEY MED CORPDERMCOM$2,478,000350,000SHNone
PHATHOM PHARMACEUTICALS INCPHATCOM$2,013,641185,589SHNone
INHIBRX BIOSCIENCES INCINBXCOM$1,922,57220,291SHNone
ENANTA PHARMACEUTICALS INCENTACOM$1,822,500125,000SHNone
HEMAB THERAPEUTICS HLDGS INCCOAGCOM SHS$1,750,25847,652SHNone
FIRST TRACKS BIOTHERAPEUTICSTRAXORD SHS$1,307,80065,000SHNone

Largest 50 positions by reported value; the filing may contain more positions.

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LIQUIDIA CORPORATIONLQDACOM NEW$195,139,1752,447,500SHNone

First displayed source row from Disclosed positions. The full bounded history and coverage notes remain below.

The displayed observation date is 2026-06-30 and its public availability date is 2026-08-15. Subtracting those calendar dates gives 46 days of disclosure lag. Historical public research can use the record from the availability date, rather than backdating knowledge to the observation date. The calendar-day difference does not assert an intraday publication time.

Read the amount together with its Unit and Option columns. A reported put or call position is not an option premium paid, and a quarterly holding is not a purchase made on its public filing date. Check every accession in the effective amendment lineage below: a retained holding can originate in an earlier filing rather than the latest linked amendment.

Open the linked original receipts to verify the row, then inspect a second record before drawing a pattern. This public filing observation supplies source evidence, not a completed copy-trading return.

How amendments affect these holdings

This view uses 1 effective filing version(s). A restatement replaces the previous book; a new-holdings amendment adds positions. 2 positions lack a resolved ticker and 0 positions are put or call entries.

The displayed holdings combine the effective filing versions listed here. The latest receipt linked below identifies the current projection version; it is not proof that every retained holding originated in that latest amendment. Inspect all effective accessions when verifying a position's source.

A 13F is a delayed quarterly snapshot of disclosed holdings. It is not a complete trade ledger and does not reveal every position in a manager's portfolio. Option values refer to the reported underlying position rather than a traded option premium.

Show the table · 1 row, 2 columns
Effective SEC accessionRole in this view
0001420506-26-001803Latest effective version

Quarter end and public filing date

Use the filing's public availability date when constructing a historical observation. The quarter-end report period is earlier and cannot be substituted for when the public learned the holdings.