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SEC Form 13F

ORBIMED ADVISORS LLC 13F Holdings

Inspect ORBIMED ADVISORS LLC's 2026-06-30 SEC 13F positions, public filing date, amendments and original receipt.

As of 2026-08-15T03:59:59.999Z

Report period
2026-06-30
Publicly available
2026-08-15
Reported value
$5,396,779,685
Positions
129
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Disclosed positions

Largest disclosed position values

Scale: 0 to 630,520,000 USD · zero baseline

Largest disclosed position values

  • EWTX · COM+630,516,330 USD
  • ELVN · COM+343,914,074 USD
  • LLY · COM+309,332,997 USD
  • MBX · COM+189,266,227 USD
  • SINOVAC BIOTECH LTD · SHS+184,466,170 USD
  • AZN · ORD+171,079,502 USD
  • GPCR · SPONSORED ADS+118,578,498 USD
  • SION · COM+112,433,029 USD
  • CRVS · COM+107,045,190 USD
  • AVBP · COM+105,169,375 USD

Reported underlying-position values for 2026-06-30, publicly available 2026-08-15. Put/call values are not option premiums; this subset is not a complete portfolio allocation. Exact issuer, class and unit remain in the table. Showing the first 10 of 50 recorded values; the complete table remains available below.

Inspect all 50 displayed rows: Disclosed positions

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EDGEWISE THERAPEUTICS INCEWTXCOM$630,516,33015,518,492SHNone
ENLIVEN THERAPEUTICS INCELVNCOM$343,914,0746,776,632SHNone
ELI LILLY & COLLYCOM$309,332,997257,900SHNone
MBX BIOSCIENCES INCMBXCOM$189,266,2273,428,736SHNone
SINOVAC BIOTECH LTDUnresolvedSHS$184,466,1702,718,735SHNone
ASTRAZENECA PLCAZNORD$171,079,502915,700SHNone
STRUCTURE THERAPEUTICS INCGPCRSPONSORED ADS$118,578,4982,209,400SHNone
SIONNA THERAPEUTICS INCSIONCOM$112,433,0292,555,877SHNone
CORVUS PHARMACEUTICALS INCCRVSCOM$107,045,1907,165,006SHNone
ARRIVENT BIOPHARMA INCAVBPCOM$105,169,3753,027,328SHNone
GUARDANT HEALTH INCGHCOM$87,572,511583,700SHNone
ARGENX SEARGXSPONSORED ADR$86,171,27892,880SHNone
MERCK & CO INCMRKCOM$85,246,900663,400SHNone
UNIQURE NVQURESHS$83,252,8051,807,486SHNone
PRAXIS PRECISION MEDICINES IPRAXCOM NEW$77,035,179230,100SHNone
EDWARDS LIFESCIENCES CORPEWCOM$75,525,054834,900SHNone
PRELUDE THERAPEUTICS INCPRLDCOM$73,151,96313,724,571SHNone
ABIVAX SAABVXSPONSORED ADS$72,829,522546,522SHNone
DYNE THERAPEUTICS INCDYNCOM$71,864,5423,235,684SHNone
NATERA INCNTRACOM$71,119,900262,000SHNone
CG ONCOLOGY INCCGONCOM$69,117,440972,800SHNone
UNITEDHEALTH GROUP INCUNHCOM$66,957,993161,100SHNone
ARS PHARMACEUTICALS INCSPRYCOM$66,390,9658,288,510SHNone
ASCENDIS PHARMA A/SASNDORD SHS$65,201,304244,456SHNone
HUMANA INCHUMCOM$65,183,802164,100SHNone
COGENT BIOSCIENCES INCCOGTCOM$65,066,3101,681,300SHNone
BOSTON SCIENTIFIC CORPBSXCOM$63,302,9761,483,200SHNone
INTUITIVE SURGICAL INCISRGCOM NEW$62,793,672157,900SHNone
MINERALYS THERAPEUTICS INCMLYSCOM$56,935,8942,110,300SHNone
ODYSSEY THERAPEUTICS INCODTXCOMMON STOCK$56,152,4153,001,198SHNone
XENON PHARMACEUTICALS INCXENECOM$53,869,550892,471SHNone
ARCUTIS BIOTHERAPEUTICS INCARQTCOM$53,541,2402,042,000SHNone
BRISTOL-MYERS SQUIBB COBMYCOM$53,298,500925,000SHNone
Q32 BIO INCQTTBCOM$52,590,5544,127,987SHNone
STRYKER CORPORATIONSYKCOM$50,091,044159,100SHNone
CARIS LIFE SCIENCES INCCAICOM$50,017,3722,806,811SHNone
SPDR SERIES TRUSTXBIST STR SP BIOT$47,475,000300,000SHPut
THERMO FISHER SCIENTIFIC INCTMOCOM$45,473,35290,700SHNone
PALVELLA THERAPEUTICS INC NEPVLACOM$44,678,455292,360SHNone
ELEVANCE HEALTH INC FORMERLYELVCOM$44,357,931114,700SHNone
SHATTUCK LABS INCSTTKCOM$43,764,5216,306,127SHNone
UPSTREAM BIO INCUPBCOM$39,399,6365,693,589SHNone
CRINETICS PHARMACEUTICALS INCRNXCOM$37,382,580999,000SHNone
RHYTHM PHARMACEUTICALS INCRYTMCOM$35,851,587322,900SHNone
SYNDAX PHARMACEUTICALS INCSNDXCOM$33,708,1201,542,000SHNone
FORTE BIOSCIENCES INCFBRXCOM NEW$33,526,2311,577,705SHNone
COMPASS THERAPEUTICS INCCMPXCOM$33,331,78715,219,994SHNone
NEKTAR THERAPEUTICSNKTRCOM NEW$32,485,804465,346SHNone
KRYSTAL BIOTECH INCKRYSCOM$30,922,94483,200SHNone
PRELUDE THERAPEUTICS INCUnresolvedNON VOTING$30,275,3915,680,186SHNone

Largest 50 positions by reported value; the filing may contain more positions.

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EDGEWISE THERAPEUTICS INCEWTXCOM$630,516,33015,518,492SHNone

First displayed source row from Disclosed positions. The full bounded history and coverage notes remain below.

The displayed observation date is 2026-06-30 and its public availability date is 2026-08-15. Subtracting those calendar dates gives 46 days of disclosure lag. Historical public research can use the record from the availability date, rather than backdating knowledge to the observation date. The calendar-day difference does not assert an intraday publication time.

Read the amount together with its Unit and Option columns. A reported put or call position is not an option premium paid, and a quarterly holding is not a purchase made on its public filing date. Check every accession in the effective amendment lineage below: a retained holding can originate in an earlier filing rather than the latest linked amendment.

Open the linked original receipts to verify the row, then inspect a second record before drawing a pattern. This public filing observation supplies source evidence, not a completed copy-trading return.

How amendments affect these holdings

This view uses 1 effective filing version(s). A restatement replaces the previous book; a new-holdings amendment adds positions. 5 positions lack a resolved ticker and 8 positions are put or call entries.

The displayed holdings combine the effective filing versions listed here. The latest receipt linked below identifies the current projection version; it is not proof that every retained holding originated in that latest amendment. Inspect all effective accessions when verifying a position's source.

A 13F is a delayed quarterly snapshot of disclosed holdings. It is not a complete trade ledger and does not reveal every position in a manager's portfolio. Option values refer to the reported underlying position rather than a traded option premium.

Show the table · 1 row, 2 columns
Effective SEC accessionRole in this view
0001172661-26-003740Latest effective version

Quarter end and public filing date

Use the filing's public availability date when constructing a historical observation. The quarter-end report period is earlier and cannot be substituted for when the public learned the holdings.